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Article

Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.

Journal of cellular physiology - 1 Feb 2005

Tabellini Giovanna, Cappellini Alessandra, Tazzari Pier Luigi, Falà Federica, Billi Anna Maria, Manzoli Lucia, Cocco Lucio, Martelli Alberto M

Abstract excerpt

The purpose of this study was to evaluate the possible involvement of the phosphoinositide 3-kinase (PI3K)/Akt survival pathway in determining resistance to arsenic trioxide (As2O3)-induced apoptosis. We employed a HL60 cell clone (HL60AR) with a constitutively active PI3K/Akt survival pathway, as well as U937 and K562 cells. In addition, we used parental (PT) HL60 cells overexpressing a constitutively active...

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Identifiers

PMID: 15316930
DOI: 10.1002/jcp.20153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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