Article
The HAMP linker in histidine kinase dimeric receptors is critical for symmetric transmembrane signal transduction.
The Journal of biological chemistry - 12 Nov 2004
Zhu Yan, Inouye Masayori
Abstract excerpt
The HAMP linker, a common structural element between a sensor and a transmitter module in various sensor proteins, plays an essential role in signal transduction. Here, by in vivo complementation experiments with Tar-EnvZ hybrid receptor mutants in which the HAMP linker forms a heterodimer with Tar and EnvZ-type subunits, we found that mutations at one linker only affect the function of EnvZ in the same subunit....
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