Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Outer breast quadrants demonstrate increased levels of genomic instability.

Annals of surgical oncology - 1 Sept 2004

Ellsworth Darrell L, Ellsworth Rachel E, Love Brad, Deyarmin Brenda, Lubert Susan M, Mittal Vimal, Hooke Jeffrey A, Shriver Craig D

Abstract excerpt

BACKGROUND: Theory holds that the upper outer quadrant of the breast develops more malignancies because of increased tissue volume. This study evaluated genomic patterns of loss of heterozygosity (LOH) and allelic imbalance (AI) in non-neoplastic tissues from quadrants of diseased breasts followi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Breast Neoplasms
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 8

Share to DNA, Neoplasm

Share to Genetic Markers

Share to Loss of Heterozygosity

Share to Mastectomy

Source

Identifiers

PMID: 15313734
DOI: 10.1245/ASO.2004.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15313734-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Outer breast quadrants demonstrate increased levels of genomic instability.PMID 15313734Read ↗

Allele Imbalance, or Loss of Heterozygosity, in Normal Breast Epithelium of Sporadic Breast Cancer Cases and BRCA1 Gene Mutation Carriers Is Increased Compared With Reduction Mammoplasty TissuesSemantic proximity Read ↗

Genomic (in)stability of the breast tumor microenvironment.Semantic proximity Read ↗

Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumorsSemantic proximity Read ↗

Accumulation of Chromosomal Imbalances From Intraductal Proliferative Lesions to Adjacent In Situ and Invasive Ductal Breast CancerSemantic proximity Read ↗

Quantitative analysis of allele imbalance supports atypical ductal hyperplasia lesions as direct breast cancer precursorsSemantic proximity Read ↗

Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactionsSemantic proximity Read ↗

Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas.Semantic proximity Read ↗

Genomic Instability Within Tumor Stroma and Clinicopathological Characteristics of Sporadic Primary Invasive Breast CarcinomaSemantic proximity Read ↗

Genomic aberrations in normal tissue adjacent to HER2-amplified breast cancers: field cancerization or contaminating tumor cells?Semantic proximity Read ↗

Cytogenetic changes in nonmalignant breast tissue.Semantic proximity Read ↗

Frequent multiplication of chromosomal region 8q24.1 associated with aggressive histologic types of breast cancers.Semantic proximity Read ↗

Positioning of necrotic lobular intraepithelial neoplasias (LIN, grade 3) within the sequence of breast carcinoma progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.