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Article

Natural Antibiotic Function of a Human Gastric Mucin Against <i>Helicobacter pylori</i> Infection

13 Aug 2004

Abstract excerpt

Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O-glycans are expressed that have terminal alpha1,4-linked N-acetylglucosamine, we tested whether these O-glycans might affect H....

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PMID: 15310903
DOI: 10.1126/science.1099250

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