Article
Age-related differences in vincristine toxicity and biodistribution in wild-type and transporter-deficient mice.
Oncology research - 1 Jan 2004
Muramatsu Toshinari, Johnson Dennis R, Finch Rick A, Johnson Linda K, Leffert Janine J, Lin Z Ping, Pizzorno Giuseppe, Sartorelli Alan C
Abstract excerpt
The impact of mouse multidrug resistance genes mdrla/b and mrpl on age-related differences in the toxicity and biodistribution of vincristine (VCR) was evaluated in wild-type, mrpl(-/-), mdrla/b(-/-), and combined mdrla/b(-/-), mrpl(-/-) weanling and adult mice given a single IP dose of VCR ranging from 0.0625 to 6 mg/kg. Weanling mice of all four genotypes were more sensitive than adult animals as determined by...
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