Article
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.
Human mutation - 1 Sept 2004
Shinmura Kazuya, Tao Hong, Yamada Hidetaka, Kataoka Hideki, Sanjar Ravshanov, Wang Jiandong, Yoshimura Kimio, Sugimura Haruhiko
Abstract excerpt
The human kallikrein 12 (KLK12) gene is a new member of the KLK gene family, some members of which are implicated in the initiation and progression of cancer. In this study, we examined 50 non-cancerous tissues from Japanese patients with primary gastric cancer to determine the presence of genetic polymorphisms in the KLK12 gene using polymerase chain reaction (PCR)-single-strand conformation polymorphism and...
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