Article
Nucleus-driven mutations of human mitochondrial DNA.
Journal of inherited metabolic disease - 1 Jan 1992
Zeviani M
Abstract excerpt
Neuromuscular disorders due to abnormalities of mitochondrial energy supply have become an important area of human pathology. In particular, lesions of the mitochondrial genome (mtDNA), a small extra-nuclear chromosome which encodes 13 subunits of the respiratory chain complexes, are responsible...
Topics
- Base Sequence
- Cell Nucleus
- Chromosome Deletion
- DNA, Mitochondrial
- Humans
- Molecular Sequence Data
- Mutation
- Neuromuscular Diseases
- Pedigree