Article
Alpha1-antitrypsin as a risk for infant and adult respiratory outcomes in a national birth cohort.
American journal of respiratory cell and molecular biology - 1 Nov 2004
Wadsworth Michael E J, Vinall Lynne E, Jones Abigail L, Hardy Rebecca J, Whitehouse David B, Butterworth Suzanne L, Hilder Warren S, Lovegrove Jennifer U, Swallow Dallas M
Abstract excerpt
Reduced alpha1-antitrypsin (AAT) encoded by the gene SERPINA1 is a potential risk for pulmonary disease. We investigated SERPINA1 polymorphism as a risk for infant and adult pulmonary morbidity, and adult respiratory function and its change between 43 and 53 yr. We used data on a British national representative sample (n = 5,362) studied since birth in 1946 to age 53 yr (when n = 3,035), when DNA was first...
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