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Article

In vitro differentiation of CD14 cells from osteopetrotic subjects: contrasting phenotypes with TCIRG1, CLCN7, and attachment defects.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2004

Blair Harry C, Borysenko Christopher W, Villa Anna, Schlesinger Paul H, Kalla Sara E, Yaroslavskiy Beatrice B, Garćia-Palacios Verónica, Oakley Jennifer I, Orchard Paul J

Abstract excerpt

UNLABELLED: We studied osteoclastic differentiation from normal and osteopetrotic human CD14 cells in vitro. Defects in acid transport, organic matrix removal, and cell fusion with deficient attachment were found. Analysis of genotypes showed that TCIRG1 anomalies correlated with acid transport defects, but surprisingly, organic matrix removal failure correlated with CLCN7 defects; an attachment defect had normal...

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Source

Identifiers

PMID: 15231021
DOI: 10.1359/JBMR.040403

Genes

CLCN7
TCIRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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