Article
QF-PCR-based prenatal detection of aneuploidy in a southeast Asian population.
Prenatal diagnosis - 1 Jun 2004
Quaife R, Wong L F, Tan S Y, Chua W Y, Lim S S, Hammersley C J N, Yeo H L
Abstract excerpt
OBJECTIVES: We have investigated the efficacy of using quantitative fluorescent polymerase chain reaction (QF-PCR) for the prenatal recognition of aneuploidy in chromosomes 13, 18, 21, X and Y. A total of 1115 samples, from mainly southeast Asian patients, were analysed and compared in a blind trial to the results previously obtained cytogenetically. METHODS: A multiplex PCR involving 15 short tandem repeat (STR)...
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