Article
RETRACTED: Computational design of a biologically active enzyme.
Science (New York, N.Y.) - 25 Jun 2004
Dwyer Mary A, Looger Loren L, Hellinga Homme W
This publication is marked as retracted by the source.
Abstract excerpt
Rational design of enzymes is a stringent test of our understanding of protein chemistry and has numerous potential applications. Here, we present and experimentally validate the computational design of enzyme activity in proteins of known structure. We have predicted mutations that introduce triose phosphate isomerase activity into ribose-binding protein, a receptor that normally lacks enzyme activity. The...
Read the complete abstract on PubMedTopics
- Algorithms
- Binding Sites
- Catalysis
- Catalytic Domain
- Computational Biology
- Computer Simulation
- Dihydroxyacetone Phosphate
- Dimerization