Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of genetic associations for complex diseases is independent of early study findings.

European journal of human genetics : EJHG - 1 Sept 2004

Trikalinos Thomas A, Ntzani Evangelia E, Contopoulos-Ioannidis Despina G, Ioannidis John P A

Abstract excerpt

Numerous genetic association studies for complex diseases are performed. Investigators place emphasis on formal statistical significance (P-values < 0.05), but the predictive ability of early statistically significant ('positive') findings is unclear. We scrutinized 55 cumulative meta-analyses of genetic associations (579 studies), in order to assess whether having statistical significance in the earliest (first)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Causality
Share to Databases, Factual

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Meta-Analysis as Topic

Share to Odds Ratio

Share to Publication Bias

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 15213707
DOI: 10.1038/sj.ejhg.5201227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of genetic associations for complex diseases is independent of early study findings.PMID 15213707Read ↗

On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studiesSemantic proximity Read ↗

Assessment of cumulative evidence on genetic associations: interim guidelines.Semantic proximity Read ↗

Reliability of statistical associations between genes and disease.Semantic proximity Read ↗

Commentary: Katan's remarkable foresight: genes and causality 18 years on.Semantic proximity Read ↗

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.Semantic proximity Read ↗

Genetic associations: false or true?Semantic proximity Read ↗

Assessing the probability that a positive report is false: an approach for molecular epidemiology studies.Semantic proximity Read ↗

Genetic associations in large versus small studies: an empirical assessment.Semantic proximity Read ↗

The Geometric Increase in Meta-Analyses from China in the Genomic EraSemantic proximity Read ↗

The impact of genome-wide association studies on biomedical research publicationsSemantic proximity Read ↗

Refining the impact of genetic evidence on clinical success.Semantic proximity Read ↗

Effect of formal statistical significance on the credibility of observational associations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.