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Article

Establishment of genetic associations for complex diseases is independent of early study findings.

European journal of human genetics : EJHG - 1 Sept 2004

Trikalinos Thomas A, Ntzani Evangelia E, Contopoulos-Ioannidis Despina G, Ioannidis John P A

Abstract excerpt

Numerous genetic association studies for complex diseases are performed. Investigators place emphasis on formal statistical significance (P-values < 0.05), but the predictive ability of early statistically significant ('positive') findings is unclear. We scrutinized 55 cumulative meta-analyses of...

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Identifiers

PMID: 15213707
DOI: 10.1038/sj.ejhg.5201227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15213707-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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