Genetic alterations of the NRP/B gene are associated with human brain tumors.

doi:10.1038/sj.onc.1207776

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Article

Genetic alterations of the NRP/B gene are associated with human brain tumors.

Oncogene - 5 Aug 2004

Liang Xing-Qun, Avraham Hava Karsenty, Jiang Shuxian, Avraham Shalom

Abstract excerpt

Nearly all brain tumors develop following the progressive accumulation of genetic alterations of oncogenes and tumor suppressor genes (such as p53 and retinoblastoma protein). Furthermore, aberrations in the nuclear matrix often contribute to genomic instabilities and the development of cancer. We have previously shown that nuclear-restricted protein/brain (NRP/B), a member of the BTB/Kelch repeat family, is a...

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Topics

Amino Acid Motifs
Apoptosis
Brain
Brain Neoplasms
Cell Division
Cell Line, Tumor
Cell Nucleus
Humans
Microfilament Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neuropeptides

Nuclear Proteins

Repetitive Sequences, Amino Acid

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 15208678
DOI: 10.1038/sj.onc.1207776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.