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Article

Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564.

Virology - 1 Jul 2004

Yuan Xiong, Huang Li, Ho Phong, Labranche Celia, Chen Chin Ho

Abstract excerpt

The HIV-1 envelope glycoprotein gp120 is the key determinant for the anti-HIV-1 entry activity of IC9564. A T198P mutation in the gp120 of the HIV-1 primary isolate, DH012, drastically increases IC9564 sensitivity, which can be reversed by growing the virus in the presence of IC9564. The reversed resistant variants contain a P198S mutation that fully confers the drug-resistant phenotype. Although the amino acid...

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PMID: 15207637
DOI: 10.1016/j.virol.2004.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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