The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses.

doi:10.1016/j.virusres.2004.02.022

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses.

Virus research - 1 Jul 2004

Seo Sang Heui, Hoffmann Erich, Webster Robert G

Abstract excerpt

The H5N1 influenza viruses transmitted to humans in 1997 were highly virulent, but the mechanism of their virulence in humans is largely unknown. Here we show that lethal H5N1 influenza viruses, unlike other human, avian, and swine influenza viruses, are resistant to the anti-viral effects of interferons and tumor necrosis factor alpha The nonstructural (NS) gene of H5N1 viruses is associated with this...

Read the complete abstract on PubMed

Topics

Animals
Cell Line
Cytokines
Drug Resistance, Multiple, Viral
Humans
Influenza A Virus, H5N1 Subtype
Influenza A virus
Influenza, Human
Interferons
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Recombination, Genetic

Swine

Tumor Necrosis Factor-alpha

Viral Nonstructural Proteins

Source

Open in PubMed

Identifiers

PMID: 15163498
DOI: 10.1016/j.virusres.2004.02.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.