Article
NS2a-NS2b sequence analysis of DEN-4 virus strains.
The Southeast Asian journal of tropical medicine and public health - 1 Sept 2003
Yao Haijun, Fang Meiyu, Zhao Wenzhong, Duan Fuqin, Lin Lihui, Chen Cuihua
Abstract excerpt
To study the genetic variability of DEN-4 Chinese isolates, and to trace the origin of DV4 Chinese isolates, we cloned and sequenced the NS2a-NS2b junction of 5 isolates and prototype DV4 (H-241). Our results show that isolates from the 1990 Guangdong epidemic, which were isolated in the early, middle, and late periods of the epidemic, share the same sequence in the NS2a-NS2b junction. The sequence similarity...
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