Article
Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004
Raguz Selina, Tamburo De Bella Manuela, Tripuraneni Gopichani, Slade Martin J, Higgins Christopher F, Coombes R Charles, Yagüe Ernesto
Abstract excerpt
PURPOSE: Activation of the MDR1 upstream promoter (USP) has been described previously in four lymphoblastic leukemia patients, where it is the major MDR1 promoter associated with P-glycoprotein overexpression. We asked whether MDR1 USP-derived transcripts were also present in breast carcinoma and assessed their potential as a biomarker. EXPERIMENTAL DESIGN: We developed a sensitive method for detecting...
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