Article
Isolation of a fluffy mutant of Aspergillus niger from chemostat culture and its potential use as a morphologically stable host for protein production.
Biotechnology and bioengineering - 5 May 2004
van de Vondervoort Peter J I, Poulsen Bjarne R, Ruijter George J G, Schuleit Tina, Visser Jaap, Iversen Jens J L
Abstract excerpt
Chemostat cultivation of Aspergillus niger and other filamentous fungi is often hindered by the spontaneous appearance of morphologic mutants. Using the Variomixing bioreactor and applying different chemostat conditions we tried to optimize morphologic stability in both ammonium- and glucose-limited cultures. In most cultivations mutants with fluffy (aconidial) morphology became dominant. From an ammonium-limited...
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