Quantitative Real‐Time Polymerase Chain‐Reaction Assay Allows Characterization ofPneumocystisInfection in Immunocompetent Mice

Abstract excerpt

Pneumocystis causes pneumonia in immunodeficient hosts but also likely causes infection in healthy hosts. To characterize infection in healthy mice, we developed and validated a real-time polymerase chain reaction assay for quantitation of Pneumocystis carinii f. sp. muris. In healthy mice exposed to Pneumocystis-infected animals, organisms were first detected at 2-3 weeks, peaked at 5-6 weeks, and were cleared...

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