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Article

Abnormal distribution and hyperplasia of thyroid C-cells in PTEN-associated tumor syndromes.

Endocrine pathology - 1 Jan 2004

Zambrano Eduardo, Holm Ingrid, Glickman Jonathan, Huang Stephen, Perez-Atayde Antonio, Kozakewich Harry P W, Shamberger Robert C, Nosé Vânia

Abstract excerpt

INTRODUCTION: Cowden's disease (CD) and Bannayan-Ruvalcaba-Riley syndrome (BRRS) are allelic disorders characterized by multiple hamartomatous overgrowths of the thyroid, breast, skin, and gastrointestinal tract, and an increased risk of developing benign and malignant tumors of the breast and thyroid gland, secondary to germline point mutations in the PTEN gene. In contrast to thyroid epithelial lesions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15067177
DOI: 10.1385/ep:15:1:55

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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