Article
p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryos
25 Mar 2004
Abstract excerpt
High embryo loss occurs in the first week of bovine embryo development, with a high percentage of embryonic arrest. We hypothesized that arrested embryos enter a 'senescence-like state' and that both the cell cycle regulatory protein p53 and the stress-related protein p66(shc), which are involved in the onset of senescence in somatic cells, are responsible for this early embryonic arrest. In our in vitro...
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