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Article

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2004

Hough Michael A, Grossmann J Günter, Antonyuk Svetlana V, Strange Richard W, Doucette Peter A, Rodriguez Jorge A, Whitson Lisa J, Hart P John, Hayward Lawrence J, Valentine Joan Selverstone, Hasnain S Samar

Abstract excerpt

More than 90 point mutations in human CuZn superoxide dismutase lead to the development of familial amyotrophic lateral sclerosis, known also as motor neuron disease. A growing body of evidence suggests that a subset of mutations located close to the dimeric interface can lead to a major destabil...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15056757
DOI: 10.1073/pnas.0305143101
PMCID: PMC395908

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15056757-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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