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Purified Recombinant Bluetongue Virus VP1 Exhibits RNA Replicase Activity

26 Mar 2004

Abstract excerpt

The polymerase protein of all known double-stranded RNA (dsRNA) viruses is located within a complex subviral core particle that is responsible for transcription of the viral genome. For members of the family Reoviridae, this particle allows messenger sense RNA synthesis while sequestering the viral genome away from cellular dsRNA surveillance systems during infection of eukaryotic cells. The core particle of...

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PMID: 15047815
DOI: 10.1128/jvi.78.8.3994-4002.2004

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