Article
Constitutional chromosome aberrations as pathogenetic events in hematologic malignancies.
Cancer genetics and cytogenetics - 1 Mar 2004
Welborn Jeanna
Abstract excerpt
A predisposition to tumor development is associated with some constitutional chromosomal abnormalities. Investigations of families with an apparent hereditary cancer and constitutional chromosome rearrangements have led to the molecular identification of tumor suppressor genes. Under the somatic mutation theory for the development of cancer, two mutational events are required. The first step may be a...
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