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The Present State of Antineoplaston Research (1)

1 Mar 2004

Abstract excerpt

Antineoplastons work as molecular switches, which regulate expression of genes p53 and p21 through demethylation of promoter sequences and acetylation of histones. They also inhibit the uptake of growth-critical amino acids, such as 1-glutamine and 1-leucine in neoplastic cells. Phase II trials indicate efficacy of antineoplastons in low-grade glioma, brain stem glioma, high-grade glioma, adenocarcinoma of the...

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PMID: 15035876
DOI: 10.1177/1534735403261964

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