Article
Typing of XY (male) genotype from malignant neoplastic tissue by the amelogenin-based sex test.
Journal of forensic sciences - 1 Mar 2004
Vauhkonen Hanna, Hedman Minttu, Vauhkonen Matti, Sipponen Pentti, Sajantila Antti
Abstract excerpt
DNA profiling of a cancer tissue can be problematic because of genomic instability. Here we have analyzed gastrointestinal cancer specimens from 46 males, of which seven (15%) showed aberrations in determination of gender by the widely used amelogenin test. The X-type amelogenin allele in all cases remained intact. All male tumor samples showing frequent autosomal loss of heterozygosity had a decreased signal of...
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