Article
[Identification of a recurrent mutation in the ROR2 gene in a Chinese family with brachydactyly type B].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2004
Yang Wei, Tan Feng-qin, Sun Miao, Zeng Xuan, Liu Jie, Liu Guo-yang, Luo Hui-yuan, Zhang Xue
Abstract excerpt
OBJECTIVE: To identify the disease-causing mutation in a Chinese family with brachydactyly type B (BDB). METHODS: Genomic DNA was extracted from peripheral blood samples of family members. Exons 8 and 9 of the ROR2 gene were amplified by polymerase chain reaction (PCR) and sequenced directly. Furthermore, the PCR products showing mutation were cloned into pMD18T vector and the insert fragments were sequenced....
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