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Article

Three novel mutations of the spastin gene in Chinese patients with hereditary spastic paraplegia.

Archives of neurology - 1 Jan 2004

Tang Beisha, Zhao Guohua, Xia Kun, Pan Qian, Luo Wei, Shen Lu, Long Zhigao, Dai Heping, Zi Xiaohong, Jiang Hong

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegia is a group of genetically heterogeneous neurodegenerative disorders characterized by progressive spasticity of the lower limbs. The most common form of hereditary spastic paraplegia is caused by mutations in the spastin gene (SPG4), which encodes spastin, an adenosine triphosphatase associated with various cellular activities protein. OBJECTIVE: To investigate the Chinese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14732620
DOI: 10.1001/archneur.61.1.49

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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