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Article

A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compounds.

Journal of bacteriology - 1 Feb 2004

Chen Ching-ju, Tobiason Deborah M, Thomas Christopher E, Shafer William M, Seifert H Steven, Sparling P Frederick

Abstract excerpt

A spontaneous point mutation in pilQ (pilQ1) resulted in phenotypic suppression of a hemoglobin (Hb) receptor mutant (hpuAB mutant), allowing gonococci to grow on Hb as the sole source of iron. PilQ, formerly designated OMP-MC, is a member of the secretin family of proteins located in the outer membrane and is required for pilus biogenesis. The pilQ1 mutant also showed decreased piliation and transformation...

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Identifiers

PMID: 14729699
DOI: 10.1128/JB.186.3.730-739.2004
PMCID: PMC321488

Genes

OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compounds.PMID 14729699Read ↗

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