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Article

PCR-based positive hybridization to detect genomic diversity associated with bacterial secondary metabolism.

Nucleic acids research - 12 Jan 2004

Pomati Francesco, Neilan Brett A

Abstract excerpt

A PCR-based positive hybridization (PPH) method was developed to explore toxic-specific genes in common between toxigenic strains of Anabaena circinalis, a cyanobacterium able to produce saxitoxin (STX). The PPH technique is based on the same principles of suppression subtractive hybridization (SSH), although with the former no driver DNA is required and two tester genomic DNAs are hybridized at high stringency....

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Identifiers

PMID: 14718552
DOI: 10.1093/nar/gnh012
PMCID: PMC373313

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