Null mutation of HvrA compensates for loss of an essential relA/spoT-like gene in Rhodobacter capsulatus.

Abstract excerpt

We report that a single relA/spoT-like gene exists on the Rhodobacter capsulatus chromosome, and its mutational loss is lethal. This gene could be mutated only under a mutational background of a null mutation in the nucleoid protein HvrA. This result suggests that there may be a direct link between HvrA-regulated promoters and the ppGpp-related stringent response.

Topics

• Amino Acid Sequence
• Bacterial Proteins
• Culture Media
• Gene Expression Regulation, Bacterial
• Guanosine Tetraphosphate
• Molecular Sequence Data
• Mutation
• NF-kappa B
• Pigments, Biological
• Pyrophosphatases
• Rhodobacter capsulatus
• Trans-Activators
• Transcription Factor RelA