Article
Autopsy findings in siblings with hypertrophic cardiomyopathy caused by Arg92Trp mutation in the cardiac troponin T gene showing dilated cardiomyopathy-like features.
Clinical cardiology - 1 Nov 2003
Shimizu Masami, Ino Hidekazu, Yamaguchi Masato, Terai Hidenobu, Uchiyama Katsuharu, Inoue Masaru, Ikeda Masatoshi, Kawashima Atsuhiro, Mabuchi Hiroshi
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by mutations in the genes that encode sarcomeric proteins. Although some patients with HCM have shown dilated cardiomyopathy (DCM)-like features, the relationship between genotype and histologic findings is not well known. HYPOTHESIS: Family members with the same gene mutation may show the same histopathologic changes and clinical manifestations. METHODS:...
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