Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia.

doi:10.1165/rcmb.2003-0338RC

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Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia.

American journal of respiratory cell and molecular biology - 1 Apr 2004

Zariwala Maimoona, O'Neal Wanda K, Noone Peadar G, Leigh Margaret W, Knowles Michael R, Ostrowski Lawrence E

Abstract excerpt

Primary ciliary dyskinesia (PCD) is an autosomal recessive disease caused by mutations that affect the proper function of cilia. Recently, deletion of DNA polymerase lambda (Poll) in mice produced a phenotype characteristic of PCD (Kobayashi et al., 2002, Mol. Cell. Biol. 22:2769-2776). Because i...

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