Article
Mapping and characterization of the dominant black colour locus in sheep.
Pigment cell research - 1 Dec 2003
Våge Dag Inge, Fleet Malcolm R, Ponz Ricardo, Olsen Ranveig T, Monteagudo Luis V, Tejedor Maria Teresa, Arruga Maria Victoria, Gagliardi Rosa, Postiglioni Alicia, Nattrass Greg S, Klungland Helge
Abstract excerpt
Dominant black pigment synthesis in sheep is caused by alterations of the melanocortin-1 receptor (MC1-R) coding sequence. Using five bovine microsatellite markers we have mapped the sheep MC1-R gene to chromosome 14, corresponding to the location in other mammalian species. The existence of two independent mutations, both causing an amino acid substitution, in distantly related breeds of sheep, support the...
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