Article
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Cancer genetics and cytogenetics - 1 Dec 2003
Alam N A, Gorman P, Jaeger E E M, Kelsell D, Leigh I M, Ratnavel R, Murdoch M E, Houlston R S, Aaltonen L A, Roylance R R, Tomlinson I P M
Abstract excerpt
Exonuclease 1 (EXO1) is a candidate gene for colorectal tumor susceptibility because it is believed to play a role in mismatch repair. There have been several studies investigating the role of EXO1 in mismatch repair but few investigating its role in causing clinical disease. In one recent study, germline variants of EXO1 were reported to be associated with predisposition to colorectal cancer in families with...
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