Article
End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens.
Molecular microbiology - 1 Oct 2003
Wenner Thomas, Roth Virginie, Fischer Gilles, Fourrier Céline, Aigle Bertrand, Decaris Bernard, Leblond Pierre
Abstract excerpt
Two mutant strains harbouring a linear chromosome whose size reached 13 Mb (versus approximately 8 Mb for the wild type) were characterized. This chromosomal structure resulted from the fusion in inverted orientation of two chromosomes partially deleted on the same arm. The fusion occurred by illegitimate recombination between 6 bp repeats. This chromosomal structure was inherited in strict association with a...
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