Article
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives.
Journal of medicinal chemistry - 20 Nov 2003
Durand Grégory, Polidori Ange, Ouari Olivier, Tordo Paul, Geromel Vanna, Rustin Pierre, Pucci Bernard
Abstract excerpt
In this study we report the synthesis of a series of new amphiphilic compounds derived from alpha-phenyl-N-tert-butylnitrone (PBN). The nitrone function was fitted into the core of the molecule between its polar and apolar groups. The polar head consisted of a lactobionamide, an ammonium, or a carboxylate group. The hydrophobic part consisted of a hydro- or a perfluorocarbon chain. The hydrophobic chain was...
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