Article
Inherited multifocal RPE-diseases: mechanisms for local dysfunction in global retinoid cycle gene defects.
Vision research - 1 Dec 2003
Besch Dorothea, Jägle Herbert, Scholl Hendrik P N, Seeliger Mathias W, Zrenner Eberhart
Abstract excerpt
Alterations of retinoid cycle genes are known to cause retinal diseases characterized by focal white dot fundus lesions. Fundus appearances reveal circumscribed RPE-changes, although generalized metabolic defects and global functional abnormalities are present. As a possible explanation, topographic inhomogeneities of the human photoreceptor mosaic and the role of a cone specific visual cycle will be discussed....
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