Methylation: a second hit in the two-hit hypothesis.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Methylation: a second hit in the two-hit hypothesis.

European journal of gynaecological oncology - 1 Jan 2003

Geisler J P, Rathe J A, Manahan K J, Geisler H E

Abstract excerpt

This case illustrates that methylation of one BRCA1 allele may serve as the second hit in a patient with a diploid locus and missense mutation on the other allele.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to DNA Methylation
Share to Gene Silencing
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Ovarian Neoplasms

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 14584644

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Methylation: a second hit in the two-hit hypothesis.PMID 14584644Read ↗

Two hits revisited again.Semantic proximity Read ↗

A fragile X sibship from a consanguineous family with a compound heterozygous female and partially methylated full mutation male.Semantic proximity Read ↗

Methylation moves into medicine.Semantic proximity Read ↗

DNA Methylation: An Alternative Pathway to CancerSemantic proximity Read ↗

Time to think outside the (genetic) box.Semantic proximity Read ↗

Rett and ICF syndromes: methylation moves into medicine.Semantic proximity Read ↗

BRCA1 haploinsufficiency: consequences for breast cancer.Semantic proximity Read ↗

DNA methylation and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.