Article
Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat.
Brain research. Molecular brain research - 21 Oct 2003
Arai Masaaki, Amano Shigeru, Ryo Akihide, Hada Akiyuki, Wakatsuki Toru, Shuda Masahiro, Kondoh Nobuo, Yamamoto Mikio
Abstract excerpt
Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21...
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