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Article

Regional heterogeneity in gene expression profiles: a transcript analysis in human and rat heart.

Cardiology - 1 Jan 2003

Sharma Saumya, Razeghi Peter, Shakir Ali, Keneson Bradley J, Clubb Fred, Taegtmeyer Heinrich

Abstract excerpt

BACKGROUND: Investigations involving biopsies of human cardiac tissue often assume that myocardial samples from a specific location are representative of the entire heart. HYPOTHESIS: There are significant regional differences in gene expression in the heart. METHODS: We used two models. In the first model, seven whole human hearts were cut in 1-cm slices from apex to base and 11 distinct regions were sampled....

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PMID: 14557693
DOI: 10.1159/000073042

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