Article
Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model.
Journal of medical virology - 1 Dec 2003
Zhang Jun, Ge Sheng X, Huang Guo Y, Li Shao W, He Zhi Q, Wang Ying B, Zheng Ying J, Gu Ying, Ng Mun H, Xia Ning S
Abstract excerpt
We have evaluated four hepatitis E virus (HEV) specific antibody assays, using sequential samples taken from 86 rhesus monkeys at intervals for up to 86 weeks after they had been infected with different doses of HEV. The animals are a common experimental model of hepatitis E. The large collection of sequential samples used avoids uncertainties encountered in previous studies regarding the precise infection status...
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