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Article

First-Trimester Screening for Trisomies 21 and 18

8 Oct 2003

Abstract excerpt

BACKGROUND: Screening for aneuploid pregnancies is routinely performed after 15 weeks of gestation and has a sensitivity of approximately 65 percent, with a false positive rate of 5 percent. First-trimester markers of aneuploidy have been developed, but their use in combination has not been adequately evaluated in clinical practice. METHODS: We conducted a multicenter study of screening for trisomies 21 and 18...

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PMID: 14534333
DOI: 10.1056/nejmoa025273

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