The correlation of age of onset with CTG trinucleotide repeat amplification in myotonic dystrophy.

doi:10.1136/jmg.29.11.774

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Article

The correlation of age of onset with CTG trinucleotide repeat amplification in myotonic dystrophy.

Journal of medical genetics - 1 Nov 1992

Hunter A, Tsilfidis C, Mettler G, Jacob P, Mahadevan M, Surh L, Korneluk R

Abstract excerpt

The gene for myotonic dystrophy (DM) has recently been isolated and amplification of an unstable CTG trinucleotide repeat, located within the DM gene, has been identified in virtually all patients studied to date. A high proportion of DM families who are studied show a progressively earlier age o...

Topics

Adolescent
Adult
Age Factors
Aged
Alleles
Base Sequence
Child
Child, Preschool
DNA Mutational Analysis
Educational Status
Female
Gene Amplification
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myotonic Dystrophy

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