Article
Late-onset distal muscular dystrophy affecting the posterior calves.
Muscle & nerve - 1 Oct 2003
Katz Jonathan S, Rando Thomas A, Barohn Richard J, Saperstein David S, Jackson Carlayne E, Wicklund Matthew, Amato Anthony A
Abstract excerpt
Miyoshi myopathy, caused by mutations in the membrane protein dysferlin, is the most common muscular dystrophy that presents in the posterior calves. Its onset is before the age of 30 years and it is associated with marked elevations of serum creatine kinase (CK). In contrast, little is known about calf myopathies with onset after the age of 30, and it is not clear whether such patients have a dysferlinopathy. We...
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