Article
A molecular fingerprint for medulloblastoma.
Cancer research - 1 Sept 2003
Lee Youngsoo, Miller Heather L, Jensen Patricia, Hernan Roberto, Connelly Michele, Wetmore Cynthia, Zindy Frederique, Roussel Martine F, Curran Tom, Gilbertson Richard J, McKinnon Peter J
Abstract excerpt
Medulloblastoma is the most common malignant pediatric brain tumor. In mice, Ptc1 haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kip1, Ink4d, or Ink4c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. To identify genes important for this tumor, we evaluated gene expression profiles in medulloblastomas from these mice....
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