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Article

beta-Lactam resistance in gram-negative bacteria: global trends and clinical impact.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Nov 1992

Sanders C C, Sanders W E

Abstract excerpt

Microbial drug resistance is an inescapable consequence of the utilization of antimicrobial agents in a given environment. Nowhere is the importance of resistance more evident than among agents of the beta-lactam family. Trends toward increased resistance can be seen among fastidious gram-negative bacteria like Haemophilus influenzae, where ampicillin resistance varies from 1% to 64% globally. For Escherichia...

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PMID: 1445981
DOI: 10.1093/clind/15.5.824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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