Article
Usefulness of a CACA repeat polymorphism in genotype assignments in Duchenne/Becker muscular dystrophy.
American journal of medical genetics - 1 Nov 1992
Miller M, Boehm C, Cotton M, Kazazian H H
Abstract excerpt
RFLP analysis in Duchenne/Becker muscular dystrophy (D/BMD) has been limited by the lack of informative marker loci at the 3' end of the dystrophin gene. Recently a CACA repeat polymorphism was described in the 3' untranslated end of the dystrophin gene which we have found helpful in genotype assignments of D/BMD families when an RFLP approach is required. The CACA repeat marker has 2 common alleles (1 and 2)...
Topics
- Base Sequence
- DNA, Single-Stranded
- Dystrophin
- Female
- Genetic Markers
- Genotype
- Humans
- Male
- Molecular Sequence Data
- Muscular Dystrophies
- Pedigree
- Polymerase Chain Reaction