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Article

Transcription of human respiratory syncytial virus genome RNA in vitro: requirement of cellular factor(s)

1 Nov 1992

Abstract excerpt

Extracts made from human respiratory syncytial virus (RSV)-infected Hep-2 cells synthesized mRNAs encoded by all known viral genes. In contrast, RSV ribonucleoproteins purified from infected cells failed to transcribe in vitro; transcription was restored by addition of a cytoplasmic extract of uninfected Hep-2 cells, demonstrating that a cellular factor(s) has a role in RSV gene expression. Quantitation of the...

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PMID: 1404620
DOI: 10.1128/jvi.66.11.6813-6818.1992

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