Article
Regulation of adhesion molecule expression by CD8 T cells in vivo. I. Differential regulation of gp90MEL-14 (LECAM-1), Pgp-1, LFA-1, and VLA-4 alpha during the differentiation of cytotoxic T lymphocytes induced by allografts.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1992
Mobley J L, Dailey M O
Abstract excerpt
A variety of adhesion molecules regulate the traffic and tissue localization of lymphocytes in vivo by mediating their binding to vascular endothelial cells. The homing receptor gp90MEL-14 (gp90), also known as LECAM-1 or L-selectin, mediates the adhesion of lymphocytes to specialized high endothelial venules in lymph nodes (LN) and is the primary molecule regulating lymphocyte recirculation and homing to LN,...
Topics
- Animals
- CD8 Antigens
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Differentiation
- Immunologic Memory
- Isoantigens
- L-Selectin
- Lymphocyte Function-Associated Antigen-1
- Mice
